Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes
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چکیده
منابع مشابه
Autologous Enhancement by Interferon of Natural Killer Activity of Human Peripheral Blood Lymphocytes
The in vitro action of interferon (IFN)-alpha and IFN-gamma from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system. The NK activity of PBL was detected by a cytotoxic test using (3)H-uridine human erythromyeloblast K562 cells. Autologous IFN-alpha and IFN-gamma did not augme...
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The inhibitory effect of ammonium choride pretreatment of human peripheral blood lymphocytes on natural killer (NK) activity to myeloid leukemic cell line K-562 was studied. The more dilute the ammonium chloride solution, the less was the inhibitory effect on NK activity. This inhibitory effect was weaker when effector cells were treated at 4° C than at 37° C. Inhibited NK activity recovered pa...
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Human peripheral blood lymphocytes of healthy donors showed significant levels of natural killer (NK) activity against erythroleukemic cell line K 562 in 3-hour 51Cr release assays. The levels of NK activity showed much individual variation, which was considered to be an individual trait that varied little under physiological conditions. The NK activity of mononuclear leukocytes from cord blood...
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Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh solid tumor cells tested. Fresh solid tumor cells were resistant to NK-mediated lysis in 10 autologous patients' PBL-tumor interactions, and fr...
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Monocytes appear to play an important role in dengue virus infection. They have been identified as cells that support dengue virus replication (1) . Dengue virus has been recovered from circulating mononuclear cells and lymphoid organs of dengue virus-infected humans and monkeys (2-4). Cell separation experiments showed that dengue virus replicates in monocyte fractions, but did not replicate i...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 1994
ISSN: 0962-9351,1466-1861
DOI: 10.1155/s0962935194000475